Related Microbes might manage your cholesterol Balskus uses chemical tools to unravel how gut microbes impact human health and disease “Much of our work has focused on elucidating how microbes in this environment are performing chemistry — what are the specific catalysts, or enzymes, that they use to perform chemical transformations that are linked to health or disease,” Balskus said. “With this knowledge, we can more accurately predict the chemistry performed by microbial communities, can begin to study its biological consequences, and can even think about developing tools to control it.”The Waterman Award, Balskus said, will allow her research team to take on higher-risk projects with potentially greater rewards and pursue creative directions that would have been impossible without NSF support.But Balskus has more than just scientific ambitions. “I hope that by receiving this award,” she said, “I can inspire women and other individuals who are underrepresented in science as well as gain a platform to highlight the challenges we currently face.” Growing up, all her science teachers were women; because of that, she didn’t hesitate to pursue a career in science.“The future of human health, of medicine, needs Emily’s research,” said Catherine Drennan, a professor of biology and chemistry at the Massachusetts Institute of Technology and one of Balskus’ collaborators. “I’m a fan of Emily. I’m just really inspired by her. And I want my 11-year-old daughter to look at her and say, ‘yes, women can do anything.’”Balskus shares the 2020 Waterman Award with John O. Dabiri, an aeronautical engineer at the California Institute of Technology. Due to the COVID-19 pandemic, the NSF postponed the original award ceremony; the agency will present Balskus and Dabiri with their awards, which include a medal and $1 million in research funding over five years, in Washington, D.C., at an unspecified date. Two plush microbes stare up at everyone who visits Emily Balskus’ office. One, a buttercup yellow, mimics the fuzzy hotdog-shaped E. coli. Another, baker’s yeast or Saccharomyces cerevisiae, is just a white sphere with eyes.Far larger than living microorganisms (and far cuter), these cuddly counterparts reveal not just Balskus’ research area, but also her admiration for her subjects. Most people fear the trillions of bacteria that live in and on the human body. But for Balskus, these microbes provide potential solutions to vast problems in human health and medicine ranging from drug metabolism to cholesterol management and even cancer.“Emily Balskus has opened up novel ways to explore and exploit the chemistry and biology of microbes that live in our bodies and how they are linked to our health,” said Sethuraman Panchanathan, director of the National Science Foundation (NSF). “And we’re already seeing the potential impact.”Today, Panchanathan announced that Balskus is one of two recipients of the Alan T. Waterman Award, the NSF’s most prestigious prize for scientists under 40 in the United States. Balskus is only the sixth Harvard scientist (and the only Harvard woman) to receive a Waterman, which the government has awarded annually since 1975.“I hope that through receiving this award I can help to bring attention to microbes, the important roles they play in all aspects of our lives, and how chemistry can help us to understand the microbial world,” said Balskus, a professor of chemistry and chemical biology. She credits her research group, past and present, for earning this award. “It means a lot to all of us to know that the scientific community is excited about our discoveries and approach to science.”To study microbes, Balskus shifted into the biological realm, but her work is still fundamentally chemical. Bacteria perform mysterious chemistry, sometimes forging or dismantling molecules using reactions that lie beyond the skills of today’s best chemists. So, Balskus hunts for microbial genes that produce enzymes, protein-based catalysts that perform chemical reactions, to understand how and why microbes do what they do.“Despite the important roles these organisms play in all habitats, we know very little about how they influence surrounding environments and organisms,” Balskus said. “We don’t understand the chemistry they perform. For example, 85 percent of genes in the human gut microbiome can’t confidently be linked to a microbial activity.”But in her latest work, Balskus and her team linked genes in the human microbiome to microbial activity, mapping, in a way, how some members of the human gut might influence their host.For example, her lab recently discovered how certain microbes break down cholesterol in the human gut. Only some people host these cholesterol-busting bacteria and those who do tend to experience lower levels of blood cholesterol. This finding could lead to new types of treatment to manage high cholesterol levels.Balskus also discovered that some gut microbes can interfere with drug metabolism, gobbling up L-dopa, for example, before the Parkinson’s treatment can reach the brain and help assuage symptoms of the disease. And, her lab played an important role in discovering how E. coli produce a harmful toxin that damages the digestive system and potentially leads to increased risk of colon cancer. Harvard microbe hunter wins Blavatnik Award Researchers discover mysterious bacteria that break it down in the gut
After 106 performances/batches of spaghetti bolognese, Skylight, starring Carey Mulligan and Bill Nighy, ended its Broadway run on June 21. The production, which took home the 2015 Tony Award for Best Revival of a Play, broke the Golden Theatre box office record in its final week, bringing in $927,539. The other big Tony-winning play of the 2014-15 season, The Curious Incident of the Dog in the Night-Time, continued to inch toward hitting seven figures once again (having done so previously over Christmas and New Year’s). Fun Home and The King and I, which received Tonys for Best Musical and Best Revival of a Musical, respectively, celebrated their highest-grossing weeks; we expect both to ride their trophy-fueled wave with rising numbers throughout the summer.Here’s a look at who was on top—and who was not—for the week ending June 21:FRONTRUNNERS (By Gross)1.The Lion King ($2,154,719)2. Wicked ($1,947,674)3. Aladdin ($1,625,997)4. The Book of Mormon ($1,517,932)5. An American in Paris ($1,440,627)UNDERDOGS (By Gross)5. On the Town ($558,807)4. Hedwig and the Angry Inch ($479,292)*3. Wolf Hall Parts One & Two ($467,890)2. Hand to God ($415,154)1. It Shoulda Been You ($344,196)FRONTRUNNERS (By Capacity)1. Fun Home (103.53%)2. The Book of Mormon (102.63%)3. The Audience (101.72%)*4. Aladdin (100.06%)5. Skylight (100.00%)=5. The Lion King (100.00%)UNDERDOGS (By Capacity)5. Jersey Boys (71.84%)4. Hedwig and the Angry Inch (71.27%)*3. It Shoulda Been You (66.08%)2. On the Town (60.82%)1. Wolf Hall Parts One & Two (44.50%)* Number based on seven regular performancesSource: The Broadway League View Comments
View Comments The Broadway.com staff is crazy for Culturalist, the website that lets you choose and create your own top 10 lists. Every week, we’re challenging you with a new Broadway-themed topic to rank. When we’re not theater-hopping (truly a perk of working here at Broadway.com), we’re cheering on all the theater folk gracing the small screens from the comfort of our living rooms. Have you noticed how many of your fave Broadway performers are killing it on TV lately? In celebration of the new fall theater and television seasons, we’re talking a look at TV shows that do a great job of featuring stage actors. Here’s the question we’re posing on Culturalist this week: Which TV show best features Broadway faves? Broadway.com Video Producer Anthony Taylor kicked off this new challenge with his list of top 10 picks here. Now it’s your turn…STEP 1—SELECT: Visit Culturalist to see all of your options. Highlight your 10 favorites and click the “continue” button.STEP 2—RANK: Reorder your 10 choices by dragging them into the correct spot on your list. Click the “continue” button.STEP 3—PREVIEW: You will now see your complete top 10 list. If you like it, click the “publish” button.Once your list is published, you can see the overall rankings of everyone on the aggregate list.Pick your favorites, then tune in for the results next week on Broadway.com!
May 1, 2004 Regular News Judicial Administration and Evaluation Committee formed through merger The merger of the Judicial Evaluation Committee and the Judicial Administration, Selection, and Tenure Committee has been approved by the Bar Board of Governors pursuant to a recommendation from the Program Evaluation Committee.PEC Chair Hank Coxe brought that recommendation to the board at its recent Pensacola meeting. PEC had discussed the matter with the board at the board’s January meeting.Coxe said PEC was recommending against including the Judicial Nominating Procedures Committee in the merger, because its duties were different enough to leave it separate.The new committee will, for the moment, be called the Judicial Administration and Evaluation Committee (JAE).The merger shows “the Bar is capable of streamlining and reducing size and numbers when it’s appropriate,” Coxe said.He also recommended waiving the term limit requirements for the leaders of the JEC to provide continuity during the merger, and the board agreed to that as part of the PEC recommendation.On other matters, Coxe said the PEC is continuing to review the Bar’s Clients Security Fund program.It is also looking at the Citizens Forum, “which was characterized as cost efficient and very valuable to the board,” Coxe said.Board member Mike Glazer, who has served on the forum, noted it has between 11 and 14 nonlawyer members from different constituencies, as well as several member. They frequently examine major issues coming to the board and have provided insightful and critical feedback on issues ranging from lawyer regulation, court funding, this year’s For The Children campaign, and other matters.“They’re input has been invaluable,” Glazer said. “If anything, we need to find ways to use them in more and better ways.”The PEC also at the board’s May meeting will be bringing recommendations from it review of the Equal Opportunities in the Profession Section and on a petition filed by Bar members to create an animal law committee, Coxe reported. Judicial Administration and Evaluation Committee formed through merger
Mr. Sheridan had not yet conceded as of early Saturday morning. During the campaign, he tried to distance himself from his old boss, who was found guilty of criminal contempt of court in 2017 for defying an order to stop detaining suspected undocumented immigrants.Mr. Sheridan defeated Mr. Arpaio, who lost his seat in 2016, in this year’s Republican primary. But he also promised to revive some of Mr. Arpaio’s most aggressive practices, and analysts saw the race as another referendum of the former sheriff’s divisive legacy. In his first term, Sheriff Penzone, while hardly a progressive on immigration issues, has closed an outdoor jail that Mr. Arpaio once called a “concentration camp,” and shut down some of his other programs. The former deputy to Joe Arpaio, whose hard-line anti-immigrant positions won him praise from President Trump, appeared headed toward a loss in the race for sheriff of Maricopa County, Ariz.The Democratic incumbent, Sheriff Paul Penzone, declared victory over Mr. Arpaio’s former deputy chief, Jerry Sheridan, in a statement on Friday, The Arizona Republic reported, and led the race by more than ten percentage points.- Advertisement – – Advertisement – – Advertisement –
Feb 27, 2008 (CIDRAP News) – The federal Advisory Committee on Immunization Practices (ACIP) today recommended influenza vaccination for all school-age children, boosting the number of children targeted for flu shots by about 30 million.The ACIP, whose recommendations are routinely adopted by the Centers for Disease Control and Prevention (CDC), said children from ages 5 through 18 should get flu shots, the CDC announced in a news release.The CDC already recommends flu shots for children from 6 to 59 months old, along with people aged 50 and older, those with certain chronic medical conditions, people in nursing homes, pregnant women, healthcare workers, and other close contacts and caregivers of those who run an increased risk of flu complications.”The expanded recommendation is to take effect as soon as feasible, but no later than the 2009-2010 influenza season,” the CDC said.The agency said healthy children bear “a significant burden” from flu. In addition, there is evidence that reducing flu transmission in children may limit its spread among their household contacts and in the community, officials said.Dr. Anne Schuchat, director of the CDC’s National Center for Immunization and Respiratory Diseases, said the recommendation should reduce children’s need for flu-related medical care and school absenteeism.Increased coverageThe CDC said the recommendation increases the number of children targeted for flu shots by about 30 million. On the basis of current vaccination rates, the agency predicts that about 7 million more children will be vaccinated as a result of the recommendation, according to a Reuters report published today.In calling for full implementation of the recommendation by the fall of 2009, the CDC said this will allow time to plan for vaccinating so many more children. “However, immunization providers should begin efforts to offer influenza vaccination to all children aged 6 months through 18 years in the 2008-09 influenza season if feasible,” the statement said.”This new recommendation will help parents understand that all children can benefit from vaccination and further encourages providers to start vaccination of children through age 18 next year,” Schuchat said.The last major expansion of flu-shot recommendations came in February 2006, when the ACIP endorsed vaccination for 2-, 3-, and 4-year-olds (ages 24 through 59 months), which added an estimated 16 million children to the targeted groups. In 2004 the CDC began recommending flu immunization for children aged 6 through 23 months.Last week the CDC reported that 22 children had died of flu so far this season. In the 2006-07 season, 68 children died of flu-related causes, including 39 who were between the ages of 5 and 17, according to CDC data. Of 53 children older than 6 months whose vaccination status was known, 50 had not been vaccinated.FluMist production to tripleIn the wake of today’s ACIP recommendation, MedImmune announced plans to raise production of its nasal-spray flu vaccine, FluMist, to 12 million doses for next season, nearly triple this year’s production. The vaccine uses a live but weakened virus.”To support this move by the ACIP, MedImmune is preparing to manufacture a record number of FluMist doses—about 12 million—for the upcoming flu season, with the intention of continuing to substantially increase production in subsequent seasons,” the company said in a news release.Dr. Frank J. Malinoski, MedImmune’s senior vice president of medical and scientific affairs, said the company’s plan to sharply boost production was partly but not wholly in anticipation of the ACIP recommendation.”We’ve been hearing from public health groups like the National Association of County and City Health Officials who’ve been saying we need to move to this next step for a while,” he told CIDRAP News. “We’ve also been hearing from customers . . . that they see a need for a needle-free vaccine as something they’re interested in and want to use more.”Malinoski said the company made about 4 million doses of FluMist for this season and sold just under that number. “We essentially sold out,” he said. In September, just before the start of flu immunization season, the Food and Drug Administration expanded the indication for FluMist to cover 2-, 3- and 4-year-olds; previously it was indicated only for healthy people aged 5 to 49 years.Malinoski predicted there will be challenges in implementing the ACIP recommendation. He added that MedImmune has seen healthcare providers use a number of innovative methods to immunize children against flu, including school-based immunization programs.”A lot of flu immunization in adults is done in the workplace, and if you think about kids, school is their workplace,” he said. “So it makes sense to do it that way.”The CDC said ACIP recommendations become CDC recommendations as soon as they are accepted by the CDC director and the secretary of the Department of Health and Human Services.See also: Feb 27 CDC news releasehttp://www.cdc.gov/media/pressrel/2008/r080227.htmCDC data on 2007-08 flu seasonhttp://www.cdc.gov/flu/weekly/weeklyarchives2006-2007/06-07summary.htmFeb 27 MedImmune news release
In 2017, a total of 508 thousand tourists stayed in non-commercial accommodation facilities (holiday homes and apartments) in the Republic of Croatia, with 12 million overnight stays. Compared to 2016, there were 7% more arrivals and 22% more tourist nights.In the structure of the total realized tourist arrivals, 28% are arrivals of domestic tourists, and 72% are arrivals of foreign tourists. In the structure of total overnight stays, 49% of overnight stays were realized by domestic tourists and 51% by foreign ones. On average, there were 24 nights per tourist. Domestic tourists spent an average of 41 nights, and foreign tourists 17 nights.Zadar County is the first in terms of the number of arrivals and overnight stays In non-commercial accommodation facilities, the highest number of tourist arrivals and overnight stays was recorded in Zadar County (27% of arrivals and 31% of overnight stays). They are followed by Primorje-Gorski Kotar (25% of arrivals and 29% of overnight stays) and Istria County (18% of arrivals and 15% of overnight stays). In other counties, 30% of tourist arrivals and 25% of overnight stays were recorded.The most numerous tourists from Slovenia In the structure of total overnight stays of foreign tourists staying in non-commercial accommodation facilities, most overnight stays were traditionally realized by tourists from Slovenia (46%). They are followed by tourists from Bosnia and Herzegovina (13%), Germany (10%), Serbia (7%), Austria (4%) and Italy and Hungary (3% each). Tourists from other countries realized 14% of tourist nights.CBS: non-commercial tourist traffic in 2017Related news:CBS: ARRIVALS AND NIGHTS, 2017
Topics : Game-changer He said the WTO had to be reformed to show its members that it could still get things done, particularly by driving through trade negotiations have been blocked up for years.”It’s a crossroads, any way you look at it,” Tuwaijri said.He said the COVID-19 crisis would change world trade and the global economy, making it “a window of opportunity to bring back the multilateral trading system” and therefore make the WTO relevant again.However, he said the moment would be short-lived and if it is missed, “we will have to deal with a much worse scenario in the years to come”.Tuwaijri said he hoped the next WTO chief would be chosen on practicality, the ability to open doors, agility, dynamics and delivery.”My ultimate wish is for the organization to really have the right person for the next four years, because it’s going to be a game-changer,” he said.Rather than elections, the WTO selects its director-general through consensus-building.Nominations closed on July 8 and the five male and three female candidates have been busy making their pitch to member states.The eight are set to be reduced to five on Friday, with a further cull to three set to take place in October and a final decision likely in November.Tuwaijri is up against Liam Fox (Britain); Abdel-Hamid Mamdouh (Egypt); Amina Mohamed (Kenya); Ngozi Okonjo-Iweala (Nigeria); Jesus Seade (Mexico); Tudor Ulianovschi (Moldova) and Yoo Myung-hee (South Korea). The WTO is in paralysis due to the trade war between the United States and China, US President Donald Trump’s mistrust of the global trade body and, according to Tuwaijri, a lack of re-evaluation within the organization itself.”Hence my approach is around practical leadership,” he said.”We need to really listen to members, but be very impartial, give ideas… gradual progress: we cannot have a switch on, switch off.” The World Trade Organization has ground to a halt and needs a pragmatic new director-general to drive through reforms, the Saudi candidate for the job said Wednesday.Mohammad al-Tuwaijri, 53, said the WTO, which was founded in 1995, was due a shake-up.”Twenty-five years; in my mind, every organization in the world — regardless of the external environment, which is severe in our case — must have the fresh restart,” he told the Geneva Press Club. Tuwaijri is one of eight candidates in the running to replace Roberto Azevedo. The Brazilian career diplomat quit the WTO helm at the end of August, a year before his second term was due to expire.Three candidates will get the chop on Friday as WTO member states narrow down the field.A former air force pilot who flew more than 30 Gulf War missions, Tuwaijri was a banker who ran JPMorgan’s fledgling Saudi Arabia operations before joining HSBC.The former Saudi economy minister currently advises the kingdom’s royal court on economic strategy.
54 Guilfoyle Circuit, KirwanWalk through the large entrance door and you’re greeted by crisp white tones, oversized dimensions, soaring ceilings and huge windows which bring the greenery indoors and provide a glimpse of the sparkling in-ground pool.The house feels fresh, airy and bright while maintaining a most welcoming feel. Owner Yvonne Venz is selling to downsize following her children moving out of home.Ms Venz and her husband designed the home to create their dream house perfect for a relaxed North Queensland lifestyle. 54 Guilfoyle Circuit, KirwanTaking pride of place in the living area is the chef’s kitchen with Miele appliances including a steam oven and integrated dishwasher, while there is a huge island bench and walk-in pantry.There is also a large, fully furnished office with built-in filing and storage cabinets while the two living rooms have ducted airconditioning with split system airconditioning to the bedrooms. 54 Guilfoyle Circuit, KirwanRay White Townsville Riverside agent Teresa Chandler said the home would appeal to a variety of buyers and was surrounded by other high-end homes.“As well as a family, this would also suit a professional couple, particularly those who like to entertain,” she said.“This is a house that someone will walk into and they are going to love it straight away.“The area here is fairly select and there are some amazing houses that would go in the millions of dollars because they are so big. Houses in this area don’t come up very often because once people move in they don’t tend to want to sell.” 54 Guilfoyle Circuit, KirwanMore from news01:21Buyer demand explodes in Townsville’s 2019 flood-affected suburbs12 Sep 202001:21‘Giant surge’ in new home sales lifts Townsville property market10 Sep 2020“I’d love to see another family come and create their memories here,” she said. “It’s a home where you can be together but there is enough space so you can go and have your own privacy and peace and quiet.”The home has 467sq m of space under-roof and is on a spacious 1016sq m block.Everything is oversized from the bedrooms, to the linen cupboard, gigantic pantry and wide patio fitted with electric blinds to block out the sun or to provide privacy. 54 Guilfoyle Circuit, KirwanTHIS isn’t your typical Kirwan home. Hidden from view down a driveway, this four-bedroom, two-bathroom house at 54 Guilfoyle Circuit, is selling for $1,150,000.There are no neighbours to the rear while the side of the home borders the Willows golf course providing a lush backdrop. 54 Guilfoyle Circuit, KirwanOutside of the home the pool, complete with waterfall, overlooks the green landscape to the rear of the property while the large patio has a built-in barbecue with cupboards and sink.There are also three automatic garages and a workshop area.
Up to 10,000 people are expected to march through Durban’s city streets, in solidarity with foreign nationals, in the wake of xenophobic attacks in South Africa. The march will be led by KwaZulu-Natal Premier Senzo Mchunu and religious leaders.Foreign nationals have been under attack in the province for the past two weeks.Overnight, police maintained a heavy presence in Durban.Officials say the march will be non-partisan and have called on people from the province to join hands and to fight the prevailing anti- foreigner sentiment.Meanwhile, Malusi Gigaba, South African Minister of Home Affairs has condemned the recent spate of violence, saying it undermined the positive contributions that foreign nationals are making to the country.